ORIGINAL ARTICLE |
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Year : 2014 | Volume
: 2
| Issue : 1 | Page : 38-43 |
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Prevalence of multi, extensively and pan drug resistant uropathogens among the women patients visiting a tertiary care hospital in central India
Trupti Bajpai1, Ganesh S Bhatambare1, Maneesha Pandey2, Meena Varma3
1 Department of Microbiology, Sri Aurobindo Institute of Medical Sciences Medical College and PG Institute, Indore, Madhya Pradesh, India 2 Department of Biochemistry, Indira Gandhi National Open University, New Delhi, India 3 Department of Biochemistry, Sri Aurobindo Institute of Medical Sciences Medical College and PG Institute, Indore, Madhya Pradesh, India
Correspondence Address:
Trupti Bajpai Department of Microbiology, Sri Aurobindo Institute of Medical Sciences Medical College, MR.10 Crossing, Indore-Ujjain Road, Indore - 453 555, Madhya Pradesh India
Source of Support: None, Conflict of Interest: None | Check |
DOI: 10.4103/2347-9019.135357
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Background: The escalation of drug resistance among the uropathogens poses a global threat. The indiscriminate, inadequate and the irrational usage of antimicrobials have contributed to the emergence of resistant strains, which may turn out to be a leading cause for the morbidity and mortality in the developing countries. Aims: The aim of the study was to provide an outlook on the prevalence of drug resistance among the isolated uropathogens. Subjects and Methods: The present study was carried out in the department of Microbiology of a teaching tertiary care hospital from July 2013 to September 2013. A total of 314 urine samples were tested, out of which 115 samples were culture positive. All the uropathogenic isolates were identified up to species level by conventional methods. Antibiotic sensitivity testing was done through disc diffusion method and all interpretations were done in accordance with the Clinical and Laboratory Standards Institute (CLSI)-2013 guidelines. Simultaneously, the extended-spectrum beta-lactamases (ESBL), Amp C and carbapenemase production mechanisms were also detected among the various isolates. Antibiotic resistance profile of the various Gram negative isolates was evaluated and the percentage prevalence of multi drug resistant(MDR), extensively drug resistant(XDR) and pan drug resistant(PDR) isolates was determined. Results: Out of the 314 urine samples tested, 120 isolates were detected among which 91 isolates were Gram negative bacilli. Among the 91 Gram negative isolates, 69 (75.8%) were MDR, 11 (12%) were XDR whereas 2 (2.1%) were PDR isolates. Conclusions: Before prescribing an empirical anti microbial therapy, an in depth knowledge of the etiology, the predisposing factors, the culture positivity and the continued evaluation of the susceptibility patterns of the uropathogens to the traditional as well as new antimicrobials is essential to avoid irrational drug usage and to ascertain the optimal prophylactic therapy. |
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