RT - Journal
TY - JOUR
A1 - Hindawi, Salwa
A1 - Radhwi, Osman
A1 - Badawi, Maha
A1 - Rajab, Hanaa
A1 - Al Mansouri, Fatma
A1 - Alzahrani, Ali
A1 - Bukhari, Hussam
A1 - Gholam, Kholoud
A1 - Almalki, Ahmad
A1 - Awadh, Abdulaziz
A1 - Yagoub, Ismat
A1 - Zaher, Galila
T1 - Outcomes of therapeutic plasma exchange: A 15-year tertiary center experience
YR - 2015/1/1
JF - International Journal of Health System and Disaster Management
JO - Int J Health Syst Disaster Manage
SP - 20
OP - 27
VO - 3
IS - 1
UL - https://www.ijhsdm.org/article.asp?issn=2347-9019;year=2015;volume=3;issue=1;spage=20;epage=27;aulast=;t=5
DO - 10.4103/ijh.ijh_2_23
N2 -
BACKGROUND: Therapeutic plasma exchange (TPE) is a treatment option used in many medical conditions. Response rates are variable as some disorders clearly benefit from TPE as first- or second-line therapy. This study aims to summarize our experience at King Abdulaziz University Hospital at King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
MATERIALS AND METHODS: In a retrospective fashion, wdemographic data, underlying disease, apheresis-related parameters, and outcomes were collected.
RESULTS: Between January 2005 and March 2020, 159 patients with 177 episodes underwent a total of 945 sessions of TPE. The majority of patients (96.8%) undergoing TPE in our center are of categories I to III according to 2019 American Society for Apheresis guidelines. Most patients had neurologic disorders, 74 (46.5%), where myasthenia gravis was the most common indication, 34 (21.4%) patients with response in 44/45 (97.8%) episodes, followed by thrombotic microangiopathies 31 (17.5%) patients with response in 17/34 (50%) episodes, Guillain–Barré syndrome 27 (16.9%) patients with recovery in 20/27 (74.1%) patients, and systemic lupus erythematous 25 (15.7%) patients with recovery in only 11/25 (44%) patients. Complications included hypotension in 29/945 (3.06%) sessions and citrate-induced symptoms in 6/945 (0.6%) sessions.
CONCLUSION: Our center complies with the recommended standards of indications for initiating TPE. Neurologic conditions constitute the largest group of patients requiring TPE.
ER -